• Eur J Pain · Feb 2014

    Smad-interacting protein 1 affects acute and tonic, but not chronic pain.

    • B Pradier, M Jeub, A Markert, D Mauer, K Tolksdorf, T Van de Putte, E Seuntjens, V Gailus-Durner, H Fuchs, M Hrabě de Angelis, D Huylebroeck, H Beck, A Zimmer, and I Rácz.
    • Institute of Molecular Psychiatry, University of Bonn Medical Center, Germany.
    • Eur J Pain. 2014 Feb 1;18(2):249-57.

    BackgroundSmad-interacting protein 1 (also named Zeb2 and Zfhx1b) is a transcription factor that plays an important role in neuronal development and, when mutated, causes Mowat-Wilson syndrome (MWS). A corresponding mouse model carrying a heterozygous Zeb2 deletion was comprehensively analysed in the German Mouse Clinic. The most prominent phenotype was the reduced pain sensitivity. In this study, we investigated the role of Zeb2 in inflammatory and neuropathic pain.MethodsFor this, we tested mutant Zeb2 animals in different models of inflammatory pain like abdominal constriction, formalin and carrageenan test. Furthermore, we studied the pain reactivity of the mice after peripheral nerve ligation. To examine the nociceptive transmission of primary sensory dorsal root ganglia (DRG) neurons, we determined the neuronal activity in the spinal dorsal horn after the formalin test using staining of c-Fos. Next, we characterized the neuronal cell population in the DRGs and in the sciatic nerve to study the effect of the Zeb2 mutation on peripheral nerve morphology.ResultsThe present data show that Zeb2 is involved in the development of primary sensory DRG neurons, especially of C- and Aδ fibres. These alterations contribute to a hypoalgesic phenotype in inflammatory but not in neuropathic pain in these Zeb2(+/-) mice.ConclusionOur data suggest that the under-reaction to pain observed in MWS patients results from a reduced responsivity to nociceptive stimulation rather than an inability to communicate discomfort.© 2013 European Pain Federation - EFIC®

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