Article Notes
One of the early papers that lit the fire under the pro-periop beta-blocker camp. Note that the legitimacy of Poldermans' DECREASE trials has been called into question due to scientific misconduct (read more)
Results from more recent trials, such as POISE greatly undermine Poldermans' rather extraordinary findings in this paper.
"Extraordinary claims require extraordinary evidence" — Carl Sagan
The legitimacy of Poldermans' DECREASE trials, in particular DECREASE IV, has been called into question due to scientific misconduct.
Results from other trials, such as POISE greatly undermine the argument for both benefit and safety of starting perioperative beta-blockade, even in high-risk patients. Read more about Poldermans and scientific misconduct.
Kinda interesting, but not too surprising given that their technique really just increases the catheterisation threshold (albeit individualized for each patient). Nonetheless the practicality and cost-effectiveness of patients pre-measuring their MBC is questionable. To avoid 27 unnecessary catheterizations they measured 931 pre-operative MBC's.