• Acta Anaesthesiol Scand · May 1996

    Randomized Controlled Trial Clinical Trial

    Reduced hypoxic chemosensitivity in partially paralysed man. A new property of muscle relaxants?

    • L I Eriksson.
    • Department of Anaesthesiology and Intensive Care, Karolinska Hospital and Institute, Stockholm, Sweden.
    • Acta Anaesthesiol Scand. 1996 May 1; 40 (5): 520-3.

    BackgroundIt was hypothesized that non-depolarizing neuromuscular blocking agents impair hypoxic chemosensitivity in man.MethodsIn thirty randomly allocated male volunteers the hypoxic and hypercarbic ventilatory responses were measured during partial paralysis (TOF ratio 0.70) due to either atracurium (n = 10), pancuronium (n = 10) or vecuronium (n = 10).ResultsHypoxic ventilatory responses were depressed by 306, 287 and 296% (mean SD) at steady-state infusion of atracurium, pancuronium and vecuronium, respectively. At a TOF ratio of > 0.90, the HVR was not different from control measurements.ConclusionIt is concluded that non-depolarizing neuromuscular blocking agents impair hypoxic ventilatory regulation. Further experimental studies are warranted to fully describe the mechanism(s) responsible for this interaction.

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