• Zhi-Hong Wen, Zong-Sheng Wu, Shi-Ying Huang, Tung-Lin Chou, Hao-Jung Cheng, Yi-Hao Lo, Yen-Hsuan Jean, and Chun-Sung Sung.
• Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan; Institute of Biopharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
• Neuroscience. 2024 Apr 22; 547: 9810798-107.

ObjectivePostoperative pain remains one of the most common complaints after surgery, and appropriate treatments are limited.MethodsWe therefore investigated the effect of the anti-nociceptive properties of magnesium sulfate (MgSO4), an N-methyl-D-aspartate (NMDA) receptor antagonist, on incision-induced postoperative pain and peripheral and central nervous system inflammation.ResultsWe found that local MgSO4 administration dose-dependently increases paw withdrawal latency, indicating reduced peripheral postoperative pain. Furthermore, MgSO4 inhibited the expression of interleukin-1β (IL-1β) and inducible nitric oxide synthase (iNOS) and phosphorylation of the NMDA receptor NR1 subunit in injured paw tissue and significantly attenuated microglial and astrocytic activation in the ipsilateral lumbar spinal cord dorsal horn.ConclusionLocally administered MgSO4 has potential for development as an adjunctive therapy for preventing central nociceptive sensitization.Copyright © 2024 IBRO. Published by Elsevier Inc. All rights reserved.

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