Journal of anesthesia
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Journal of anesthesia · Mar 1994
Changes of oxygen transport variables and serum lactate during open-chest cardiac massage in dogs.
The aim of this study was to investigate the influence of critically low cardiac output (CO) upon oxygen transport. We especially focused on the changes of mixed venous oxygen saturation (S-vO2) in the presence of oxygen consumption ([Formula: see text]) debts. Additionally, we examined the correlation between the cumulative oxygen deficit (Def[Formula: see text]) and serum lactate. ⋯ Supplydependent[Formula: see text] was observed when CO decreased below 40 ml·min-1·kg-1. The mean value of S-vO2 in the range of supply-dependent[Formula: see text] was 13±2% and did not change significantly during 1 h of CPR. The changes of lactate from baseline values were linearly correlated with Def[Formula: see text] (r=0.62,P<0.01), but absolute values of serum lactate were not.
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Journal of anesthesia · Mar 1994
Subanesthetic sevoflurane does not affect sympathetic or parasympathetic function.
To evaluate the effects of subanesthetic enflurane and sevoflurane on the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS), the blood level of norepinephrine (NE) and fluctuations in the R-R intervals were measured on electrocardiogram in humans given either 0.5 MAC enflurane or sevoflurane. Enflurane suppressed circulating plasma NE and elevated coefficients of variation (CV) of R-R intervals after 20 and 30 min of inhalation. ⋯ Sevoflurane lowered the CV to 84% of control after 30 min of inhalation. These results indicate that subanesthetic concentrations of sevoflurane are unlikely to perturb sympathetic and parasympathetic activities in humans without surgical stimulation when compared with enflurane.
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Journal of anesthesia · Mar 1994
Sevoflurane reduced but isoflurane maintained hepatic blood flow during anesthesia in man.
The indocyanine green (ICG) clearance rate (K) and estimated total hepatic blood flow (THBF) were studied by the single injection technique. The THBF was estimated from the calculated circulating blood volume and the fixed extraction rate. The blood concentration of ICG was determined by the finger piece technique. ⋯ ICG (0.5 mg·kg-1) was administered intravenously and K was determined three times following the injection. The K value in the halothane and sevoflurane groups decreased significantly 1 h after induction of anesthesia: from 0.188±0.048 to 0.142±0.029 in the halothane group and from 0.178±0.027 to 0.155±0.021 in the sevoflurane group. There was no significant change in the K value in the isoflurane group throughout the study.
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Journal of anesthesia · Mar 1994
Effects of a forced-air system (Bair Hugger, OR-type) on intraoperative temperature in patients with open abdominal surgery.
Intraoperative hypothermia is difficult to avoid and may present a significant clinical risk during the early postoperative phase. We evaluated a forced-air system [Bair Hugger, OR-type (BH)] for warming intraoperative patients with open abdominal surgery. Twenty patients received BH warming [BH(+) group] and another 20 patients, who served as controls, did not [BH(-) group]. ⋯ Rectal and fingertip temperatures in the BH(+) group were significantly higher than those in the BH(-) group, and central-peripheral temperature gradients in the BH(+) group were significantly smaller than those in the BH(-) group during the study, except at 180 min. No shivering occurred in either group. Therefore, BH is an effective warming device during open abdominal surgery.