Annals of surgery
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To investigate whether revision of pancreatic neck margin based on intraoperative frozen section analysis has oncologic value in post-neoadjuvant pancreatoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC). ⋯ Conversion of an initially positive pancreatic neck margin by additional resection is not associated with oncologic benefits in post-neoadjuvant PD and cannot be routinely recommended.
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Randomized Controlled Trial Multicenter Study Pragmatic Clinical Trial
2 days versus 5 days of Postoperative Antibiotics for Complex Appendicitis: Cost Analysis of a Randomized, Non-inferiority Trial.
To compare costs for 2 days versus 5 days of postoperative antibiotics within the antibiotics after an aPPendectomy In Complex appendicitis trial.Background:Recent studies suggest that restrictive antibiotic use leads to a significant reduction in hospital stays without compromising patient safety. Its potential effect on societal costs remains underexplored. ⋯ Two days of postoperative antibiotics for complex appendicitis results in a statistically significant and relevant cost reduction, as compared with 5 days. Findings apply to laparoscopic appendectomy in a well-resourced health care setting.
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To use a customized smartphone application to prospectively measure QOL and the real-time patient experience during neoadjuvant therapy (NT). ⋯ While patient symptom burden remains high, results of this prospective cohort study suggest QOL is maintained during NT for localized GI cancers.