Knowledge
Collections of articles, notes and knowledge from the metajournal community.
Airway
Analgesia
Anesthesia
Complications
Covid
Critical care
Decision making
Drugs
Epidural
Intrathecal
Intravenous anesthetics
Neuromuscular agents
Obstetric anesthesia
Opioid
Pain
Pediatric anesthesia
Perioperative medicine
Postoperative complications
Regional anesthesia
Sugammadex
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- Does peri-operative intravenous dexamethasone reduce pain and opioid consumption after caesarean delivery? YES
- Are the effects statistically significant? YES
- Are the effects clinically significant? Possibly, though pain scores are only modestly improved and the reduction in opioid use is only small.
- Are the findings applicable to my patient population? Possibly, though the majority of studies were performed in Middle East, Asian & South Asian hospitals, and with diverse post-operative analgesic regimes.
- Is peri-operative dexamethasone safe? Probably, though few studies were adequately powered to identify less-common potential side effects, such as infection or delayed wound healing.
- Quality of evidence is low to modest. Notably, the primary outcome for most studies was PONV reduction, not post-operative pain.
- Should this evidence result in routine practice change? Probably not at this stage. IV dexamethasone may however be an appropriate intervention in select patient groups.
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