The Australian & New Zealand journal of obstetrics & gynaecology
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Aust N Z J Obstet Gynaecol · Nov 1993
Randomized Controlled Trial Comparative Study Clinical TrialKetorolac versus fentanyl for gynaecological day-case surgery.
The effectiveness of fentanyl and ketorolac in providing analgesia for day-case gynaecological procedures was evaluated in 55 healthy volunteers in a single blinded fashion. Fentanyl (1 mcg/kg iv) and ketorolac (30 mg im) were administered immediately following induction of anaesthesia. Anaesthesia was standardized with propofol, nitrous oxide and enflurane. ⋯ There was no significant difference between the 2 groups with respect to any of the measured variables. Both drugs were ineffective as sole analgesic agents in half of their respective groups. It may be that a combination of these drugs, providing a multireceptor approach to analgesia, will prove to be more effective.
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Aust N Z J Obstet Gynaecol · May 1992
Randomized Controlled Trial Comparative Study Clinical TrialA comparison of tiaprofenic acid, mefenamic acid and placebo in the treatment of dysmenorrhoea in general practice.
The efficiency and side-effects of tiaprofenic acid, mefenamic acid and placebo were compared in the treatment of primary dysmenorrhoea. The trial was a double-blind prospective randomized 3-way crossover study during 6 successive menstrual cycles following a 2-cycle run-in period and involved 50 women with primary dysmenorrhoea selected from 96 volunteers between 16 and 35 years of age. Overall pain was significantly less (p less than 0.05) on treatment with tiaprofenic acid than on treatment with mefanemic acid, placebo, or the women's usual treatments. Both active treatments were well tolerated but more side-effects were reported during treatment with mefenamic acid.
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Aust N Z J Obstet Gynaecol · Feb 1986
Randomized Controlled Trial Comparative Study Clinical TrialPreoperative cervical dilatation: a trial of laminaria tents and prostaglandin F2 alpha gel.
Surgical damage to the cervix in patients undergoing termination of pregnancy may be responsible for serious complications in subsequent pregnancies. Sixty nulliparous women undergoing first trimester termination of pregnancy were randomly allocated to 3 treatment groups, one using laminaria tents preoperatively, one using intracervical PGF2 alpha gel preoperatively and one using no pretreatment. ⋯ There were no differences in blood loss or postoperative complications among the 3 groups. Laminaria tents provide a cheap, effective and safe method of reducing the risk of cervical damage in women undergoing surgical termination of pregnancy.
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Aust N Z J Obstet Gynaecol · Aug 1979
Randomized Controlled Trial Clinical TrialInhibition of puerperal lactation: evaluation of bromocriptine and placebo.
Bromocriptine and placebo were randomly allocated to 50 patients who wished to suppress lactation. Patients on bromocriptine suffered no subjective symptoms such as breast pain and engorgement, and lactation was significantly reduced compared with patients on the placebo with or without breast binding. No side-effects were noted, and rebound lactation was seen in only 3 patients. In most patients contraceptives were commenced once the drug therapy ceased on the fourteenth day.