Article Notes
Article pearls, summaries and comments.
Second-generation supraglottic airway devices have a role in selected patients undergoing general anaesthesia for cesarean section.
Daniel Jolley
There is high variation in the duration of action of a single dose of neuromuscular blocking drugs in children.
Daniel Jolley
Care by female anaesthetists is associated with a lower risk of intraoperative complications, particularly among specialist anaesthetists.
Daniel Jolley
The agnostic respiratory stimulant ENA-001 blocks carotid body BK-channels, reversing propofol's impairment of the hypoxic ventilatory response.
Daniel Jolley
- Does peri-operative intravenous dexamethasone reduce pain and opioid consumption after caesarean delivery? YES
- Are the effects statistically significant? YES
- Are the effects clinically significant? Possibly, though pain scores are only modestly improved and the reduction in opioid use is only small.
- Are the findings applicable to my patient population? Possibly, though the majority of studies were performed in Middle East, Asian & South Asian hospitals, and with diverse post-operative analgesic regimes.
- Is peri-operative dexamethasone safe? Probably, though few studies were adequately powered to identify less-common potential side effects, such as infection or delayed wound healing.
- Quality of evidence is low to modest. Notably, the primary outcome for most studies was PONV reduction, not post-operative pain.
- Should this evidence result in routine practice change? Probably not at this stage. IV dexamethasone may however be an appropriate intervention in select patient groups.
Daniel Jolley
Intravenous dexamethasone modestly reduces post-caesarean section pain.
Daniel Jolley
Permissive intra-operative hypotension (MAP ≤60 mmHg) was not associated with increased mortality, but perplexingly was associated with reduced AF and hospital stay.
Daniel Jolley
Perioperative benzodiazepine use is associated with decreased risk of intraoperative awareness but no increase in postoperative delirium unless compared with dexmedetomidine.
Daniel Jolley
Transdermal & buccal buprenorphine is associated with a small reduction in pain scores in chronic non-cancer pain.
Daniel Jolley
Interesting rat study suggesting a hypothesis for the neuroprotective effects of hypothermia on cerebrocortical damage arising from hypoxia and hypoglycaemia.
Daniel Jolley
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