Gastrointestinal endoscopy
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Gastrointest. Endosc. · May 2016
Randomized Controlled Trial Comparative StudyA Phase IIb Study Comparing the Safety and Efficacy of Remimazolam and Midazolam in Patients Undergoing Colonoscopy.
Remimazolam is an ultra-short-acting benzodiazepine currently being developed for procedural sedation and for induction and maintenance of anesthesia. This trial was the fourth study for procedural sedation. The aim was to compare the safety and efficacy profile of remimazolam and to refine suitable doses for subsequent phase III studies in this indication. ⋯ NCT01145222.).
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Gastrointest. Endosc. · May 2016
Randomized Controlled Trial Comparative StudyA randomized, controlled trial to compare the efficacy and safety profile of a dexmedetomidine-ketamine combination with a propofol-fentanyl combination for ERCP.
Moderate to deep levels of sedation and analgesia are required for ERCP. Propofol-based sedation is simple, easy to use, and effective, but is not without cardiovascular and respiratory adverse effects. The combination of dexmedetomidine and ketamine (DK) has shown promising results for sedation in other similar scenarios. The aim of this study was to compare the efficacy and safety of a standard propofol-fentanyl (PF) regimen with a DK combination. ⋯ There were significantly fewer sedation-related adverse effects, but the recovery time was longer with DK.
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Gastrointest. Endosc. · Sep 2014
Randomized Controlled Trial Multicenter StudyA randomized, controlled trial of oral sulfate solution plus polyethylene glycol as a bowel preparation for colonoscopy.
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Gastrointest. Endosc. · Aug 2014
Randomized Controlled TrialA randomized controlled trial assessing the effect of prescribed patient position changes during colonoscope withdrawal on adenoma detection.
High-quality colonoscope withdrawal technique is associated with a higher adenoma detection rate. Position change is routinely used in barium enema and CT colonography to facilitate adequate distension of the colon and promote movement of fluid from the segment of the colon being assessed. ⋯ NCT01395173.).
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Gastrointest. Endosc. · May 2014
Randomized Controlled Trial Multicenter StudyCan patient and pain characteristics predict manometric sphincter of Oddi dysfunction in patients with clinically suspected sphincter of Oddi dysfunction?
Biliopancreatic-type postcholecystectomy pain, without significant abnormalities on imaging and laboratory test results, has been categorized as "suspected" sphincter of Oddi dysfunction (SOD) type III. Clinical predictors of "manometric" SOD are important to avoid unnecessary ERCP, but are unknown. ⋯ NCT00688662.).