Lancet neurology
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Serogroup B meningococcal disease is the commonest cause of meningitis and septicaemia in high-income countries. Assessment of new serogroup B meningococcal vaccines is hampered by a scarcity of data on the burden of disease in survivors. We aimed to estimate the disease burden in children having survived serogroup B meningococcal disease. ⋯ Meningitis Trust and Big Lottery Fund, UK.
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Alternating hemiplegia of childhood (AHC) is a rare neurological disorder characterised by early-onset episodes of hemiplegia, dystonia, various paroxysmal symptoms, and developmental impairment. Almost all cases of AHC are sporadic but AHC concordance in monozygotic twins and dominant transmission in a family with a milder phenotype have been reported. Thus, we aimed to identify de-novo mutations associated with this disease. ⋯ Eva Luise and Horst Köhler Foundation for Humans with Rare Diseases.
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Factors such as inactivity, poor nutrition, smoking, and depression could contribute to an increased risk of dementia in prisoners. But limited prison resources mean that even simple measures to reduce these risks might not be implemented. Mario Christodoulou reports.
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Comment Letter
Restenosis after carotid artery stenting: remaining issues.