Lancet neurology
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Studies in rodent models of epilepsy suggest that multidrug efflux transporters at the blood-brain barrier, such as P-glycoprotein, might contribute to pharmacoresistance by reducing target-site concentrations of antiepileptic drugs. We assessed P-glycoprotein activity in vivo in patients with temporal lobe epilepsy. ⋯ EU-FP7 programme (EURIPIDES number 201380).
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Biography Historical Article
Paolo Calabresi: the supremo of synaptic plasticity.