African health sciences
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African health sciences · Sep 2012
The long-term effectiveness of generic adult fixed-dose combination antiretroviral therapy for HIV-infected Ugandan children.
Access to pediatric antiretroviral formulations is increasing in resource-limited countries, however adult FDCs are still commonly used by antiretroviral therapy (ART) programs. ⋯ Treatment with generic adult FDC for HIV-infected Ugandan children led to sustained clinical, immunologic and virologic response during 96 weeks of ART. Early initiation of ART is key to achieving virological success.
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African health sciences · Sep 2012
Fungal pathogens and primary antifungal prophylaxis in patients with hematological malignancies: one year experience.
Febrile neutropenia (FN) is generally a complication of cancer chemotherapy in patients with hematological malignancies. ⋯ It is obvious that more studies focused on primary prophylaxis are needed and primary or secondary antifungal prophylaxis should be evaluated in terms of provided benefits and disadvantages. Timely and appropriately initiated antifungal treatment is one of the most important factors for a good prognosis for recovery from a neutropenic phase.
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African health sciences · Sep 2012
Clinical and epidemiologic characteristics of nodding syndrome in Mundri County, southern Sudan.
Nodding syndrome (repetitive nodding and progressive generalized seizures) is assuming epidemic proportions in South Sudan, Tanzania and Uganda. ⋯ Nodding Syndrome was strongly associated with Onchocerca volvulus. There was no evidence to suggest an environmental pollutant, chemical agent, or other toxic factor.
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African health sciences · Sep 2012
Sabin and wild type polioviruses from children who presented with acute flaccid paralysis in Nigeria.
Sensitive poliovirus surveillance to detect vaccine-derived-polioviruses will continue to increase in importance. ⋯ This study further confirms the presence of Sabin and wild-type poliovirus among children in Nigeria. The isolation of Sabin strain of poliovirus is advantageous to the polio eradication program as it is capable of inducing natural immunity in susceptible hosts. Transmission of wild-type poliovirus among children with incomplete vaccination poses a serious threat to polio eradication program in Nigeria. Environmental and serological surveillance with larger sample size are important for monitoring poliovirus circulation in Nigeria.