African health sciences
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African health sciences · Dec 2016
Post-transplant withdrawal of lamivudine results in fatal hepatitis flares in kidney transplant recipients, under immune suppression, with inactive hepatitis B infection.
To evaluate the consequences of lamivudine withdrawal in kidney transplant recipients, under immunosuppression, with inactive hepatitis B virus (HBV) infection. ⋯ Lamivudine should be continued as long as immunosuppressive therapy lasts.
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African health sciences · Dec 2016
Socio-demographic correlates of treatment response among patients with schizophrenia in a tertiary hospital in South-East Nigeria.
Many patients with schizophrenia respond poorly to antipsychotic medication. Few studies have systematically examined the relationship of social and demographic characteristics of these patients to treatment response in our environment. ⋯ Knowledge about these variables in relation to treatment response would improve mental health services as regards articulation of prognosis and psycho education.
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African health sciences · Dec 2016
Glyceryl trinitrate is a novel inhibitor of quorum sensing in Pseudomonas aeruginosa.
Targeting quorum sensing is an alternative approach to antibiotics.Targeting quorum sensing-regulated virulence will disarm the pathogen without exerting pressure on its growth. As a result, emergence of resistance is avoided and the immune system can easily eradicate bacteria. ⋯ Glyceryl trinitrate can be an antivirulence agent in the treatment of Pseudomonas aeruginosa topical infections such as burn infections.
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African health sciences · Dec 2016
Exercise alleviates depression related systemic inflammation in chronic obstructive pulmonary disease patients.
Depression is a highly prevalent co-morbidity in Chronic Obstructive Pulmonary Disease (COPD) which was shown to be associated with a worse course of disease, including reduced quality of life and increased symptoms burden, healthcare use, and even mortality. It has been speculated that systemic inflammation may play a role in the presence of depression. Currently, physical activity is an important lifestyle factor that has the potential to modify inflammatory cytokines and depression, however our understanding of how to use exercise effectively in COPD patients to alleviate depression related systemic inflammation is incomplete and has prompted our interest to identify the type and intensities of effective exercise. ⋯ Aerobic exercise is an effective treatment policy to improve depression related to systemic inflammation in patients with chronic obstructive pulmonary disease.
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African health sciences · Dec 2016
Chemical constituents of Cyperus rotundus L. and their inhibitory effects on uterine fibroids.
Xiang Fu (Cyperus rotundus L) enters the liver, spleen and triple warmer meridians, and has qi stagnation-removing, qi circulation-promoting, menstruation-regulating and pain-relieving effects. Besides, it can improve ovarian function, and has hypolipidemic, hypoglycemic and neuroprotective actions. ⋯ It concludes that amentoflavone has a significant inhibitory effect on uterine tumors in rats. Its mechanism may be by elevating Bax protein expression, down-regulating Bcl-2 expression, forming homodimers Bax/Bax, and reducing plasma estradiol and progesterone to promote apoptosis of uterine fibroid cells.