African health sciences
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African health sciences · Dec 2018
Comparative Studycomparative study of carbohydrate antigen 19-9 in sickle cell disease subjects and controls in Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Sickle cell disease is characterized by chronic complications that affect almost all body organs. Pancreatic disease is rare in SCD. CA 19-9 is a non-specific surrogate marker for pancreatic disease especially carcinoma. CA 19-9 levels have not been evaluated in SCD patients in our environment. ⋯ Low levels of CA 19-9 in Hb SS may suggest reduced pancreatic disorders in SCA.
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African health sciences · Dec 2018
Randomized Controlled TrialImpact of weight reduction on insulin resistance, adhesive molecules and adipokines dysregulation among obese type 2 diabetic patients.
Type 2 diabetes mellitus is usually related to vascular problems and is associated with impairment in endothelial function characterized by impaired endothelial-dependent vasodilation and increased platelet adhesion. There is limitation in clinical studies that have addressed the beneficial effects of weight reduction in modulating biomarkers of endothelial dysfunction and adipokines dysregulation for obesity associated with type 2 diabetes mellitus. ⋯ Within the limit of this study, 10% reduction in body mass index modulates insulin resistance, adhesive molecules and adipokines dysregulation among obese type 2 diabetic patients.
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African health sciences · Dec 2018
Interferon-γ receptor-1 gene promoter polymorphisms and susceptibility for brucellosis in Makkah region.
Genetic polymorphisms that affect the production levels of certain cytokines and/or their receptors may determine the risk, severity or protection in some infectious diseases like brucellosis. ⋯ Both tested polymorphisms, IFN-γ R1 - 56 C>T and IFN-γ R1 -611 A>G polymorphism had no role in genetic susceptibility to human brucellosis in the study population. The PCR-CTPP can be used for genotyping IFN-γ R1 - 611 A > G polymorphism and other types of mutation.
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African health sciences · Dec 2018
Randomized Controlled TrialWalking as a feasible means of effecting positive changes in BMI, waist, and blood pressure in black South African women.
In the context of a growing obesity pandemic in sub-Saharan African countries little is known on how to address the problem /disease in the region. ⋯ Our data demonstrates that positive changes in BMI, waist, and BP were observed in the intervention group, indicating the potential scalability of the intervention.
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African health sciences · Dec 2018
Audit of insulin prescription patterns and associated burden among diabetics in a tertiary health institution in Nigeria.
Insulin is one of the most important anti-diabetic agents in the management of diabetes even among type 2 diabetic. ⋯ The insulin adherence among diabetics in this study was high. Non-availability of insulin, insulin injection pain and being tired of continual insulin usage were some of the reasons for non-adherent to insulin usage.