African health sciences
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African health sciences · Jun 2022
IL-4 gene polymorphisms and their association with nematodes infection in Pakistani population.
Interleukin-4 (IL-4) plays a central role in the humoral immune defense against nematode parasite infections, inducing IgE switch and regulation of worm expulsion from the intestines. The present study aimed to investigate the polymorphisms in IL-4 gene and their association with socio-demographic and environmental factors among patients with gastrointestinal complaints. ⋯ IL-4 gene polymorphisms showed disease susceptibility and consuming raw/unwashed vegetables, poor handwashing practices and poor economic status were the most associated factors with the disease.
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African health sciences · Jun 2022
Meta AnalysisAssociation between hair dye use and cancer in women: a systematic review and meta-analysis of case-control studies.
The use of hair dye for cosmetic purposes appears to be increasing worldwide. As 50-80% of women use hair dye throughout their lifetimes, the possible association between hair dye use and cancer is a public health concern. ⋯ The present study suggests that, although the use of hair dye may increase the risk of cancer among users, a more detailed evaluation is required to assess the type of hair dye use in terms of guidelines and metrics.
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African health sciences · Jun 2022
Meta AnalysisThe comparison of remimazolam and midazolam for the sedation of gastrointestinal endoscopy: a meta-analysis of randomized controlled studies.
Remimazolam and midazolam are used for the sedation of gastrointestinal endoscopy, but their efficacy remains controversial. We conduct a systematic review and meta-analysis to compare the sedation of remimazolam with midazolam for gastrointestinal endoscopy. ⋯ Remimazolam demonstrated better efficacy and safety for the sedation of gastrointestinal endoscopy compared to midazolam.
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African health sciences · Jun 2022
ReviewA five-year retrospective review of the maternal and feotal outcome of obstructed labour and its determinants in a tertiary hospital in Nigeria.
Obstructed labour is one of the common obstetric emergencies in Nigeria which is associated with an increased maternal and foetal complications. ⋯ The commonest cause of obstructed labour in our review is cephalopelvic disproportion occurring more in primiparous women. Wound infection is the commonest maternal complication with majority of the neonates having a good outcome. Provision of free antenatal care services, education of women on the importance of antenatal care, early presentation in the hospital and early use of broad spectrum antibiotics would help to reduce the associated complications.
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African health sciences · Jun 2022
Barriers to uptake of cervical cancer screening among women in Nigeria: a systematic review.
Cervical cancer is the second most frequent cancer and cause of cancer-related deaths among women in Nigeria. The Visual inspection with acetic acid and cryotherapy "see and treat" screening approach is a feasible and effective method that can be implemented in low resource settings like Nigeria; however, screening utilization is still low. ⋯ Lack of adequate information about cervical cancer is a significant hindrance to screening; this factor is strongly associated with the numerous misconceptions and negative perceptions. The study highlights the need for further assessment of the sociodemographic determinants of cervical cancer screening uptake in Nigeria. Preventive strategies should be targeted at improving the dissemination of valid information, reducing the knowledge gap among women, and addressing the financial and health service factors.