Medicina clinica
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An adverse drug reaction (ADR) is defined as a response to a medicinal product which is noxious and unintended. ADRs are an important cause of morbidity and mortality and increase health costs. ⋯ Spontaneous notification of ADR is the cheapest, simplest and most used method to recognize new safety drug problems, under-reporting being its main limitation. The future of pharmacovigilance and ADRs will include a higher involvement of patients, doctors, health authorities and pharmaceutical companies, and the use of new technologies.
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Case Reports Observational Study
Effect of dapagliflozin on arterial stiffness in patients with type 2 diabetes mellitus.
Oral antidiabetic inhibitors of the sodium-glucose cotransporter (SGLT2i) reduce cardiovascular morbidity and mortality in DM2. The increase in arterial stiffness can participate in this morbidity and mortality. The aim of this study was to analyse the effect of the administration of dapagliflozin on arterial stiffness. ⋯ Dapagliflozin, in subjects with DM2, produces a medium to long-term decrease in arterial stiffness.
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Observational Study
Predictive factors of hyperglycaemia in patients with parenteral nutrition.
To identify the predictive factors of hyperglycaemia in patients receiving parenteral nutrition (PN). ⋯ Decreased renal clearance, high blood glucose levels, diabetes, corticosteroid use, and critical patients are predictors of hyperglycaemia, therefore it would be advisable to consider them in the design of PN start formula.