Medicina clinica
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This systematic review aims to analyze the validity and reliability of available tools to assess health-related quality of life (HRQoL) and exercise tolerance in children and adolescents with cystic fibrosis (CF). ⋯ The CFQ-R, cycloergometry and the modified shuttle test have the best properties for the assessment of children with CF, but more studies are needed.
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Case Reports
Standard versus extended primary cytomegalovirus prophylaxis in solid organ transplantation.
We compared the efficacy and safety of standard vs. extended primary cytomegalovirus (CMV) prophylaxis in solid organ transplantation. ⋯ Extending primary CMV prophylaxis over 100 days did not prevent late-onset infection but it was associated with hematological toxicity.
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Case Reports
Benefits of early use of high-flow-nasal-cannula (HFNC) in patients with COVID-19 associated pneumonia.
Severe COVID-19 is associated with hypoxemic bilateral pneumonia that leads to mechanical ventilation in a considerable proportion of patients. To the best of our knowledge, there are no recommendations about the best time to initiate high flow nasal cannula (HFNC). ⋯ Early HFNC use is associated with a decrease in the need for intubation, mortality and overall hospital stay.
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Observational Study
Vascular target organ damage in patients with Philadelphia negative myeloproliferative syndrome: A propensity score analysis.
To assess whether subjects with Philadelphia negative myeloproliferative neoplasms (Ph-MPNs) show differences in the presence of vascular, cardiac or renal target organ damage (TOD) and other vascular function parameters as compared to individuals without this condition. ⋯ Subjects with Ph-MPNs have twice the risk of by carotid injury than those without haematological disease.