Medicina clinica
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Observational Study
Impact of systemic therapies on SARS-CoV-2 antibody seroprevalence in patients with immune-mediated diseases.
To determine the seroprevalence of SARS-CoV-2 in patients with immune-mediated inflammatory diseases (IMID) treated with biologic (bDMARDs) or synthetic targeted disease-modifying antirheumatic drugs (tsDMARDs). ⋯ Patients on treatment with TNFα inhibitors have better humoral response compared to the other b/tsDMARDs. However, when associated with methotrexate the seroprevalence decreases significantly.
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Observational Study
Impact of influenza vaccination history in the clinical course of older adults hospitalized with COVID-19.
Some studies have shown that influenza vaccination is associated with a lower risk of SARS-CoV-2 infection; in patients with COVID-19 infection, admission to intensive care is reduced, with less need for mechanical ventilation, shorter hospital stays, and reduced mortality. This study aimed to determine if a history of annual influenza vaccination impacts the clinical course of SARS-CoV-2 infection during hospitalization. ⋯ In this study, a history of influenza vaccination in older adults with SARS-CoV-2 infection was related to lower in-hospital mortality.
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Comment Letter Case Reports
Side effects of urea for the treatment of hyponatremia in heart failure.