Journal of the National Comprehensive Cancer Network : JNCCN
The most recent articles from:
J Natl Compr Canc Netw
-
J Natl Compr Canc Netw · Jan 2003
ReviewEpidermal growth factor receptor as a target in cancer therapy.
Epithelial cancers have been found to overexpress the receptor to epidermal growth factor (EGFR). These include head and neck, breast, colon, lung, prostate, kidney, ovary, brain, pancreas, and bladder. ⋯ Antibodies such as IMC-C225 specifically target EGFRs, whereas tyrosine kinase inhibition by many small molecules is less specific but is also effective. This report focuses on EGFR and novel compounds that target it.