Revista da Associacao Medica Brasileira (1992)
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Rev Assoc Med Bras (1992) · Jul 2022
Diagnostic value of serum levels of galanin and obestatin in patients with gastric cancer.
Gastric cancer ranks the third among the cancer-related deaths. It is diagnosed at advanced stage in many patients due to malignant proliferation and has a poor prognosis. Currently, no instrument or biomarker has been proven to diagnose the disease before the advanced stages. This study aimed to measure the serum levels of galanin and obestatin, which were examined in various studies including cancer studies, and to discuss their diagnostic value in gastric cancers. ⋯ Serum levels of galanin were lower and serum levels of obestatin were higher in patients with gastric cancer compared to the healthy individuals. Serum levels of obestatin and galanin can be used as potential biomarkers in the diagnosis of gastric cancer.
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Rev Assoc Med Bras (1992) · Jul 2022
Human enteroviral infection in fibromyalgia: a case-control blinded study.
This study aimed to test the hypothesis that fibromyalgia is associated with a human enteroviral infection. ⋯ The results of this systematic study do not support the hypothesis that fibromyalgia is associated with infection by a human enterovirus.
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Rev Assoc Med Bras (1992) · Jul 2022
Antitumor activity of irinotecan with ellagic acid in C6 glioma cells.
Irinotecan-based combination chemotherapies in malignant gliomas need to be examined. The aim of this study was to investigate the synergetic effect of ellagic acid, a natural polyphenolic antioxidant compound, with irinotecan, an inhibitor of topoisomerase I enzyme, on the growth, cadherin switch, and angiogenic processes of a glioma cell line. ⋯ Further research is required to prove a negative relationship between C6 glial cell proliferation and irinotecan with ellagic acid application. Our preliminary data suggest that even with the extremely short-term application, irinotecan with ellagic acid may affect glioma cells at the level of gene and protein expression.
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[This corrects the article doi: 10.1590/1806-9282.20220147].