Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Apr 2014
Randomized Controlled Trial Multicenter StudyTreatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at 3 months: multicenter double-blind, placebo-controlled randomized trial.
Acute pulmonary embolism (PE) can worsen quality of life due to persistent dyspnea or exercise intolerance. ⋯ Treatment of patients with submassive pulmonary embolism with tenecteplase was associated with increased probability of a favorable composite outcome.
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J. Thromb. Haemost. · Nov 2013
Multicenter StudyVariable D-dimer thresholds for diagnosis of clinically suspected acute pulmonary embolism.
Computed tomography pulmonary angiography (CTPA) is frequently requested using diagnostic algorithms for suspected pulmonary embolism (PE). For suspected deep vein thrombosis, it was recently shown that doubling the D-dimer threshold in patients with low pretest probability safely decreased the number of ultrasonograms. We evaluated the safety and efficiency of a similar strategy in patients with suspected PE. ⋯ Applying selective D-dimer thresholds reduces the need for CTPA by 11 percentage points but is associated with an increased failure rate. Prospective studies should evaluate the safety and net clinical benefit of this approach.
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J. Thromb. Haemost. · Oct 2013
Randomized Controlled Trial Multicenter Study Comparative StudyComparison of fondaparinux with low molecular weight heparin for venous thromboembolism prevention in patients requiring rigid or semi-rigid immobilization for isolated non-surgical below-knee injury.
In several small studies, anticoagulant therapy reduced the incidence of venous thromboembolism (VTE) in patients with isolated lower-limb injuries. ⋯ Fondaparinux 2.5 mg day(-1) may be a valuable therapeutic option over nadroparin 2850 anti-FXa IU day(-1) for preventing VTE after below-knee injury requiring prolonged immobilization in patients with additional risk factors.
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J. Thromb. Haemost. · Jul 2013
Randomized Controlled Trial Multicenter StudyA randomized controlled trial of fresh frozen plasma for treating venom-induced consumption coagulopathy in cases of Australian snakebite (ASP-18).
Venom-induced consumption coagulopathy (VICC) is a major effect of snake envenoming. ⋯ FFP administration after antivenom administration results in more rapid restoration of clotting function in most patients, but no decrease in discharge time. Early FFP administration (< 6-8 h) post-bite is less likely to be effective.
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J. Thromb. Haemost. · May 2013
Randomized Controlled Trial Multicenter StudyActivated protein C attenuates pulmonary coagulopathy in patients with acute respiratory distress syndrome.
Acute respiratory distress syndrome (ARDS) frequently complicates critical illness. We hypothesized that an infusion of recombinant human activated protein C (rh-APC), a natural anticoagulant, would attenuate pulmonary coagulopathy and injury. ⋯ An infusion of rh-APC in patients with ARDS attenuates pulmonary coagulopathy and injury.