Chinese medical journal
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Chinese medical journal · Dec 2019
Screening of MYH7 gene mutation sites in hypertrophic cardiomyopathy and its significance.
There have been few reports of mutations in the beta-myosin heavy chain (MYH7) gene in hypertrophic cardiomyopathy (HCM), which is associated with sudden cardiac death caused by HCM. This study aimed to screen the mutation sites in the sarcomeric gene MYH7 in Chinese patients with HCM. We also planned to analyze the pathogenicity of the mutation site as well as its significance in clinical and forensic medicine. ⋯ Our results showed fatal HCM harbored mutations of Thr446Pro and Phe468Leu in the MYH7 gene. It is significant for clinical and forensic medicine to further explore the functions and detailed mechanisms of these mutations.
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Chinese medical journal · Dec 2019
Deep neural network-assisted computed tomography diagnosis of metastatic lymph nodes from gastric cancer.
Artificial intelligence-assisted image recognition technology is currently able to detect the target area of an image and fetch information to make classifications according to target features. This study aimed to use deep neural networks for computed tomography (CT) diagnosis of perigastric metastatic lymph nodes (PGMLNs) to simulate the recognition of lymph nodes by radiologists, and to acquire more accurate identification results. ⋯ Through deep learning, FR-CNN achieved high judgment effectiveness and recognition accuracy for CT diagnosis of PGMLNs.
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Chinese medical journal · Dec 2019
ReviewPathogenesis, disease course, and prognosis of adult-onset Still's disease: an update and review.
Adult-onset Still's disease (AOSD) is a rare but clinically well-known polygenic systemic autoinflammatory disease. In this review, we aim to present frontiers in the pathogenesis, clinical features, diagnosis, biomarkers, disease course, prognosis, and treatment in AOSD. ⋯ This review highlights the advances in pathogenesis, potential biomarkers, disease course, and treatment in AOSD.