Chinese medical journal
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Chinese medical journal · May 2022
Identification of clusterin as a serum biomarker candidate contributed to the lung fibroblasts activation in chronic obstructive pulmonary disease.
Fibrosis in the peripheral airways contributes to airflow limitation in patients with chronic obstructive pulmonary disease (COPD). However, the key proteins involved in its development are still poorly understood. Thus, we aimed to identify the differentially expressed proteins (DEPs) between smoker patients with and without COPD and elucidate the molecular mechanisms involved by investigating the effects of the identified biomarker candidate on lung fibroblasts. ⋯ Our findings suggest that CLU may play significant roles during airway fibrosis in COPD by regulating lung fibroblast activation.