Chinese medical journal
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Chinese medical journal · Apr 2023
Genetic background of idiopathic neurodevelopmental delay patients with significant brain deviation volume.
Significant brain volume deviation is an essential phenotype in children with neurodevelopmental delay (NDD), but its genetic basis has not been fully characterized. This study attempted to analyze the genetic factors associated with significant whole-brain deviation volume (WBDV). ⋯ Idiopathic NDD patients with significant brain volume changes detected by MRI had an increased prevalence of motor development delay, which could be explained by the genetic differences characterized herein.