Chinese medical journal

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• Chinese medical journal · Jan 2025

  Gut microbiota and their metabolites in hemodialysis patients.

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• Chinese medical journal · Jan 2025

  Treatment efficacy for relapsed/refractory multiple myeloma patients with gain/amplification 1q21.

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• Chinese medical journal · Jan 2025

  Life's Essential 8 cardiovascular health metrics and long-term risk of cardiovascular disease at different stages: A multi-stage analysis.

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• Chinese medical journal · Jan 2025

  Assessment of genetic associations between antidepressant drug targets and various stroke subtypes: A Mendelian randomization approach.

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• Chinese medical journal · Jan 2025

  EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis.

  Knee osteoarthritis (OA) is still challenging to prevent or treat. Enhanced endoplasmic reticulum (ER) stress and increased pyroptosis in chondrocytes may be responsible for cartilage degeneration. This study aims to investigate the effect of ER stress on chondrocyte pyroptosis and the upstream regulatory mechanisms, which have rarely been reported. ⋯ A novel EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis and cartilage degeneration by regulating ER stress in OA, contributing novel mechanistic insights into OA pathogenesis and providing potential targets for future therapeutic research.

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