Emergency medicine Australasia : EMA
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Emerg Med Australas · Dec 2013
Randomized Controlled Trial Multicenter StudyRationale and methodology for a multicentre randomised trial of fibrinolysis for pulmonary embolism that includes quality of life outcomes.
Submassive pulmonary embolism (PE) has a low mortality rate but can degrade functional capacity. ⋯ An investigator-initiated, FDA-regulated, multicentre trial of fibrinolysis for submassive PE was conducted, but was limited by screening costs and a low mortality rate. Quality of life measurements might represent a more important patient-centred end-point.
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Emerg Med Australas · Dec 2013
Randomized Controlled TrialIntravenous 0.9% sodium chloride therapy does not reduce length of stay of alcohol-intoxicated patients in the emergency department: A randomised controlled trial.
I.v. 0.9% sodium chloride (normal saline) is frequently used to treat ED patients with acute alcohol intoxication despite the lack of evidence for its efficacy. ⋯ I.v. normal saline therapy added to observation alone does not decrease ED length of stay compared with observation alone. Intoxication symptom scores and general state of intoxication were similar in both groups. The present study suggests that either approach is reasonable, but observation alone might be preferred as it is less resource intensive.
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Emerg Med Australas · Dec 2013
Letter Randomized Controlled TrialAmitriptyline versus tizanidine in the management of tension-type headache in Nepal.
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Emerg Med Australas · Oct 2013
Randomized Controlled Trial Multicenter StudyAustralasian Resuscitation In Sepsis Evaluation trial statistical analysis plan.
The Australasian Resuscitation In Sepsis Evaluation (ARISE) study is an international, multicentre, randomised, controlled trial designed to evaluate the effectiveness of early goal-directed therapy compared with standard care for patients presenting to the ED with severe sepsis. ⋯ A statistical analysis plan for the ARISE study has been developed, and is available in the public domain, prior to the completion of recruitment into the study. This will minimise analytic bias and conforms to current best practice in conducting clinical trials.
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Emerg Med Australas · Jun 2013
Randomized Controlled Trial Comparative StudyAdministration of metoclopramide by infusion or bolus does not affect the incidence of drug-induced akathisia.
The study aims to determine if slow intravenous infusion of metoclopramide reduces the incidence of acute drug-induced akathisia (DIA) compared with intravenous bolus. ⋯ The incidence of DIA and reduction in nausea is unaffected by the rate of administration of intravenous metoclopramide 20 mg.