Acta neurochirurgica
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Acta neurochirurgica · Jan 1980
Effect of antifibrinolytic therapy on subarachnoid fibrosis in dogs after experimental subarachnoid haemorrhage.
The effect of antifibrinolytic therapy on posthaemorrhagic subarachnoid fibrosis was observed experimentally in dogs with the scanning electron microscope (SEM). The subchronic subjects, given intravenous injections of tranexamic acid (1 mg/day) for 12 days and sacrificed 3 weeks after cisternal blood injection, showed residual clot with thick fibrosis, especially around the haemorrhage. ⋯ Tranexamic acid is widely used for preventing the recurrence of subarachnoid haemorrhage. However, it was revealed in this study that antifibrinolytic therapy might increase chronic posthaemorrhagic subarachnoid fibrosis, which is considered to be responsible for communicating hydrocephalus by disturbing epicortical CSF flow.
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Acta neurochirurgica · Jan 1979
Some scanning electron microscopic observations of the ependymal surface of the ventricles of hydrocephalic Hy3 mice and a human infant.
Two hydrocephalic Hy 3 mice and an infant with hydrocephalus and the Arnold-Chiari malformation were examined with the scanning electron microscope. Both mice had advanced hydrocephalus but had normal appearances in the basal regions of the ventricles. ⋯ The infant had mild hydrocephalus and normal ependymal appearances. The most likely explanation of these findings is that they are a consequence of raised intracranial pressure, and are not the cause of hydrocephalus.