PLoS medicine
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Previous studies of drug trials submitted to regulatory authorities have documented selective reporting of both entire trials and favorable results. The objective of this study is to determine the publication rate of efficacy trials submitted to the Food and Drug Administration (FDA) in approved New Drug Applications (NDAs) and to compare the trial characteristics as reported by the FDA with those reported in publications. ⋯ Many trials were still not published 5 y after FDA approval. Discrepancies between the trial information reviewed by the FDA and information found in published trials tended to lead to more favorable presentations of the NDA drugs in the publications. Thus, the information that is readily available in the scientific literature to health care professionals is incomplete and potentially biased.
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Editorial
Scaling up international food aid: food delivery alone cannot solve the malnutrition crisis.
ThePLoS Medicine Editors discuss what role food aid should play in addressing the global childhood malnutrition crisis.
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Randomized Controlled Trial
The long-term effects of a peer-led sex education programme (RIPPLE): a cluster randomised trial in schools in England.
Peer-led sex education is widely believed to be an effective approach to reducing unsafe sex among young people, but reliable evidence from long-term studies is lacking. To assess the effectiveness of one form of school-based peer-led sex education in reducing unintended teenage pregnancy, we did a cluster (school) randomised trial with 7 y of follow-up. ⋯ Compared with conventional school sex education at age 13-14 y, this form of peer-led sex education was not associated with change in teenage abortions, but may have led to fewer teenage births and was popular with pupils. It merits consideration within broader teenage pregnancy prevention strategies.
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David Ross discusses a new study of school-based peer-led sex education in London and whether it reduced unintended teenage pregnancy.