PLoS medicine
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Comparative Study
The effect of automated alerts on provider ordering behavior in an outpatient setting.
Computerized order entry systems have the potential to prevent medication errors and decrease adverse drug events with the use of clinical-decision support systems presenting alerts to providers. Despite the large volume of medications prescribed in the outpatient setting, few studies have assessed the impact of automated alerts on medication errors related to drug-laboratory interactions in an outpatient primary-care setting. ⋯ Providers will adhere to alerts and will use this information to improve patient care. Specifically, in response to drug-laboratory interaction alerts, providers will significantly increase the ordering of appropriate laboratory tests. There may be a concomitant change in adverse drug events that would require a larger study to confirm. Implementation of rules technology to prevent medication errors could be an effective tool for reducing medication errors in an outpatient setting.
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Comparative Study
Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer.
While lymph node metastasis is among the strongest predictors of disease-free and overall survival for patients with breast cancer, the immunological nature of tumor-draining lymph nodes is often ignored, and may provide additional prognostic information on clinical outcome. ⋯ These findings demonstrate that the immune profile of tumor-draining lymph nodes is of novel biologic and clinical importance for patients with early stage breast cancer.
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The dramatic protests that shut down trials of tenofovir as pre-exposure prophylaxis against HIV may prove damaging in our fight against the HIV pandemic.
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The international AIDS community is being held hostage by a small number of activist groups, argues Lange.