Alzheimer's & dementia : the journal of the Alzheimer's Association
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Multicenter Study
The pilot European Alzheimer's Disease Neuroimaging Initiative of the European Alzheimer's Disease Consortium.
In North America, the Alzheimer's Disease Neuroimaging Initiative (ADNI) has established a platform to track the brain changes of Alzheimer's disease. A pilot study has been carried out in Europe to test the feasibility of the adoption of the ADNI platform (pilot E-ADNI). ⋯ Academic EADC centers can adopt the ADNI platform to enroll MCI and AD patients and older controls with global cognitive and structural imaging features remarkably similar to those of the US-ADNI.
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Progress in understanding the pathogenesis of Alzheimer's disease (AD) has advanced rapidly and has achieved parity in knowledge with other chronic degenerative diseases of the elderly. This knowledge has not yet been successfully translated into new and effective disease-modifying drugs. ⋯ Nevertheless, primary prevention of AD remains the ultimate and most important goal of research efforts because the unique clinical features of this dementing disease create a number of challenges for drug development, regulatory approval, and payment. Ultimately, the development of truly effective disease-modifying drugs through accelerated drug discovery is the only real pathway to primary prevention.