Clinical toxicology : the official journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
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Clin Toxicol (Phila) · Dec 2013
Case ReportsDelayed bupropion cardiotoxicity associated with elevated serum concentrations of bupropion but not hydroxybupropion.
Bupropion overdose commonly causes generalized seizures and central nervous system depression. Less commonly, cardiotoxicity has been reported. The toxicity of the parent drug compared to its active metabolite hydroxybupropion is uncertain. ⋯ Cardiotoxicity appears to be caused primarily by bupropion rather than its active metabolite hydroxybupropion.
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Clin Toxicol (Phila) · Dec 2013
Fatalities involving acetaminophen combination products reported to United States poison centers.
Deaths from overdose of acetaminophen (APAP) combination medications are reported, yet the individual ingredients are not well examined as individual putative causes of death. ⋯ The most common putative cause of death in fatal overdoses involving APAP combination products reported to US poison centers is the APAP component.
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Clin Toxicol (Phila) · Nov 2013
Comparative StudyPerformance of clinical scoring systems in acute organophosphate poisoning.
Clinical scoring systems are used to predict mortality rate in hospitalized patients. Their utility in organophosphate (OP) poisoning has not been well studied. ⋯ In acute OP poisoning, the generic scoring systems APACHE-II and SAPS-II outperform the PSS. These tools may be used to predict the mortality rate in OP poisoning.
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Clin Toxicol (Phila) · Nov 2013
Comparative StudyCharacterizing risk factors for pediatric lamp oil product exposures.
Poisonings from lamp oil ingestion continue to occur worldwide among the pediatric population despite preventive measures such as restricted sale of colored and scented lamp oils. This suggests that optimal prevention practices for unintentional pediatric exposures to lamp oil have yet to be identified and/or properly implemented. ⋯ Lamp oil product exposures are most common among young children (around 2 years of age) while at home, not alone and likely as a result of the product being in a child-accessible location. Increasing parental awareness about potential health risks to children from these products and teaching safe storage and handling practices may help prevent both exposures and associated illness. These activities may be of greater benefit in Midwestern states and during summer months (including the period around the July 4th holiday).