Clinics
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The promotion of extracellular matrix synthesis by chondrocytes is a requisite part of an effective cartilage tissue engineering strategy. The aim of this in vitro study was to determine the effect of bi-axial cyclic mechanical loading on cell proliferation and the synthesis of glycosaminoglycans by chondrocytes in three-dimensional cultures. ⋯ These results demonstrate that the use of a bi-axial loading regime results in increased matrix production compared with uni-axial loading.