Clinics
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Randomized Controlled Trial Multicenter Study
Goal-directed therapy in patients with early acute kidney injury: a multicenter randomized controlled trial.
Acute kidney injury is associated with many conditions, and no interventions to improve the outcomes of established acute kidney injury have been developed. We performed this study to determine whether goal-directed therapy conducted during the early stages of acute kidney injury could change the course of the disease. ⋯ Goal-directed therapy for patients in the early stages of acute kidney injury did not change the disease course.
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Randomized Controlled Trial Multicenter Study
A phase III, randomized, non-inferiority study comparing the efficacy and safety of biosimilar filgrastim versus originator filgrastim for chemotherapy-induced neutropenia in breast cancer patients.
To compare the efficacy and safety of two filgrastim formulations for controlling chemotherapy-induced neutropenia and to evaluate the non-inferiority of the test drug relative to the originator. ⋯ The efficacy and safety profile of the test drug were similar to those of the originator product based on the rate of grade 4 neutropenia in the first treatment cycle. This study supports Anvisa's approval of the first biosimilar drug manufactured by the Brazilian industry (Fiprima¯).
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Multicenter Study Observational Study
Giant cell arteritis: a multicenter observational study in Brazil.
To describe demographic features, disease manifestations and therapy in patients with giant cell arteritis from referral centers in Brazil. ⋯ Most of the clinical features of Brazilian giant cell arteritis patients were similar to those found in other studies, except for the high prevalence of neuro-ophthalmic manifestations and permanent blindness in the Brazilian patients. Aspirin had a protective effect on relapses.
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Randomized Controlled Trial Multicenter Study Comparative Study
Comparative multicenter study of treatment of multi-fragmented tibial diaphyseal fractures with nonreamed interlocking nails and with bridging plates.
A prospective, randomized study to compare patients with closed, multi-fragmented tibial diaphyseal fractures treated using one of two fixation methods undertaken during minimally invasive surgery: nonreamed interlocking intramedullary nails or bridging plates. ⋯ The healing time was shorter with the bridging plate technique, although no significant functional differences were found.