Clinical journal of the American Society of Nephrology : CJASN
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Clin J Am Soc Nephrol · Aug 2015
Low Systemic Oxygen Delivery and BP and Risk of Progression of Early AKI.
The optimal hemodynamic management of patients with early AKI is unknown. This study aimed to investigate the association between hemodynamic parameters in early AKI and progression to severe AKI and hospital mortality. ⋯ Higher DO2I and MAP in early AKI were independently associated with a lower risk of progression.
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Clin J Am Soc Nephrol · Aug 2015
Multicenter Study Comparative Study Observational StudyA Prospective International Multicenter Study of AKI in the Intensive Care Unit.
AKI is frequent and is associated with poor outcomes. There is limited information on the epidemiology of AKI worldwide. This study compared patients with AKI in emerging and developed countries to determine the association of clinical factors and processes of care with outcomes. ⋯ This study contrasts the clinical features and management of AKI and demonstrates worse outcomes in emerging than in developed countries. Differences in variations in care may explain these findings and should be considered in future trials.
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Quantitative data for prediction of incidence and progression of early CKD are scarce in individuals with type 2 diabetes. Therefore, two risk prediction models were developed for incidence and progression of CKD after 5.5 years and the relative effect of predictors were ascertained. ⋯ Albuminuria and eGFR were the most important factors to predict onset and progression of early CKD in individuals with type 2 diabetes. However, their predictive ability is modest. Inclusion of demographic, clinical, and other laboratory predictors barely improved predictive performance.
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Clin J Am Soc Nephrol · Aug 2015
Editorial CommentThe Golden Hours of AKI: Is Oxygen Delivery the Key?