Clinical journal of the American Society of Nephrology : CJASN
-
Clin J Am Soc Nephrol · Apr 2010
Randomized Controlled Trial Multicenter Study Comparative StudyA randomized controlled study comparing once-weekly to every-2-week and every-4-week dosing of epoetin alfa in CKD patients with anemia.
Extended-interval dosing of epoetin alfa (EPO) is commonly used to treat anemia in patients with chronic kidney disease (CKD). This study aimed to demonstrate that EPO dosed every 2 weeks (Q2W) and every 4 weeks (Q4W) was noninferior to once-weekly (QW) dosing. ⋯ Q2W and Q4W EPO dosing maintained Hb levels in subjects with stage 3 to 4 CKD. Deaths, thromboembolic vascular events, and serious adverse events were comparable across the dosing groups.
-
Clin J Am Soc Nephrol · Apr 2010
Randomized Controlled Trial Multicenter StudyA phase III, randomized, double-blind, placebo-controlled study of tenecteplase for improvement of hemodialysis catheter function: TROPICS 3.
Despite widespread use of tunneled hemodialysis (HD) catheters, their utility is limited by the development of thrombotic complications. To address this problem, this study investigated whether the thrombolytic agent tenecteplase can restore blood flow rates (BFRs) in dysfunctional HD catheters. ⋯ Tenecteplase improved HD catheter function and had a favorable safety profile compared with placebo.
-
Clin J Am Soc Nephrol · Jul 2009
Randomized Controlled Trial Multicenter Study Comparative StudyContrast-induced nephropathy and long-term adverse events: cause and effect?
The relationship of contrast-induced nephropathy (CIN) to long-term adverse events (AEs) is controversial. Although an association with AEs has been previously reported, it is unclear whether CIN is causally related to these AEs. ⋯ The parallel decrease in the incidence of CIN and AEs in one arm of this randomized trial supports a causal role for CIN.
-
Clin J Am Soc Nephrol · May 2009
Multicenter Study Comparative StudyEstimating glomerular filtration rate: Cockcroft-Gault and Modification of Diet in Renal Disease formulas compared to renal inulin clearance.
Evaluation of renal function by estimation of the glomerular filtration rate (GFR) is very important for the diagnosis and treatment of patients with chronic kidney disease (CKD). The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) formulas are the most commonly used estimations. ⋯ The CG and MDRD formulas had some limitations for proper GFR estimation and K/DOQI-CKD classification by GFR levels alone.
-
Clin J Am Soc Nephrol · Mar 2009
Multicenter StudyEpoetin therapy and hemoglobin level variability in nondialysis patients with chronic kidney disease.
Intrapatient variability of hemoglobin (Hb) is a newly proposed determinant of adverse outcome in chronic kidney disease (CKD). We evaluated whether intensity of epoetin therapy affects Hb variability and renal survival in nondialysis CKD. ⋯ Lack of adjustment of EPO worsens Hb variability in CKD. Hb variability may be associated with renal survival, but further studies are needed to explore the association versus causal relationship.