Social cognitive and affective neuroscience
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Soc Cogn Affect Neurosci · Nov 2015
Threat/reward-sensitivity and hypomanic-personality modulate cognitive-control and attentional neural processes to emotional stimuli.
Temperamental-traits (e.g. threat/reward-sensitivity) are found to modulate cognitive-control and attentional-processes. Yet, it is unclear exactly how these traits interact with emotional-stimuli in the modulation of cognitive-control, as reflected by the N2 event-related potential (ERP), and attentional-processes, as reflected by the P2 and P3 ERPs. Here in an ERP emotional-Go/NoGo task, 36 participants were instructed to inhibit their response to Fearful- and Happy-faces. ⋯ Conversely, the modulation of attentional-processing was specific to threat-sensitivity, as there was no relationship between either reward-sensitivity or hypomanic-personality and attentional-processing. Elevated threat-sensitivity was associated with enhanced early (P2s) and later (P3s) attentional-processing to Fearful-NoGo (relative to Happy-NoGo) faces. These latter findings support the negative attentional-bias model relating elevated threat-sensitivity with attentional-biases toward negative-stimuli and away from positive-stimuli.
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Soc Cogn Affect Neurosci · May 2015
BDNFval66met affects neural activation pattern during fear conditioning and 24 h delayed fear recall.
Brain-derived neurotrophic factor (BDNF), the most abundant neutrophin in the mammalian central nervous system, is critically involved in synaptic plasticity. In both rodents and humans, BDNF has been implicated in hippocampus- and amygdala-dependent learning and memory and has more recently been linked to fear extinction processes. Fifty-nine healthy participants, genotyped for the functional BDNFval66met polymorphism, underwent a fear conditioning and 24h-delayed extinction protocol while skin conductance and blood oxygenation level dependent (BOLD) responses (functional magnetic resonance imaging) were acquired. ⋯ During early extinction, 24h later, we again observed heightened responses in several regions ascribed to the fear network in met-carriers as opposed to val-carriers (insula, amygdala, hippocampus), which likely reflects fear memory recall. No differences were observed during late extinction, which likely reflects learned extinction. Our data thus support previous associations of the BDNFval66met polymorphism with neural activation in the fear and extinction network, but speak against a specific association with fear extinction processes.
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Soc Cogn Affect Neurosci · May 2015
Neural coding of assessing another person's knowledge based on nonverbal cues.
For successful communication, conversational partners need to estimate each other's current knowledge state. Nonverbal facial and bodily cues can reveal relevant information about how confident a speaker is about what they are saying. Using functional magnetic resonance imaging, we aimed to identify brain regions that encode how confident a speaker is perceived to be. ⋯ Our results suggest a distinct role of two neural networks known to support social inferences, the so-called mentalizing and the mirroring network. While activation in both networks underlies the processing of nonverbal cues, only activity in the mentalizing network, most notably the medial prefrontal cortex and the bilateral temporoparietal junction, is modulated by how confident the respondent is judged to be. Our results support an integrative account of the mirroring and mentalizing network, in which the two systems support each other in aiding pragmatic processing.
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Soc Cogn Affect Neurosci · Jun 2014
Experimental human endotoxemia enhances brain activity during social cognition.
Acute peripheral inflammation with corresponding increases in peripheral cytokines affects neuropsychological functions and induces depression-like symptoms. However, possible effects of increased immune responses on social cognition remain unknown. Therefore, this study investigated the effects of experimentally induced acute inflammation on performance and neural responses during a social cognition task assessing Theory of Mind (ToM) ability. ⋯ Social cognition performance was not affected by acute inflammation. However, altered neural activity was observed during the ToM task after LPS administration, reflected by increased responses in the fusiform gyrus, temporo-parietal junction, superior temporal gyrus and precuneus. The increased task-related neural responses in the LPS condition may reflect a compensatory strategy or a greater social cognitive processing as a function of sickness.
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Soc Cogn Affect Neurosci · Dec 2009
Variation in orbitofrontal cortex volume: relation to sex, emotion regulation and affect.
Sex differences in brain structure have been examined extensively but are not completely understood, especially in relation to possible functional correlates. Our two aims in this study were to investigate sex differences in brain structure, and to investigate a possible relation between orbitofrontal cortex subregions and affective individual differences. We used tensor-based morphometry to estimate local brain volume from MPRAGE images in 117 healthy right-handed adults (58 female), age 18-40 years. ⋯ Men had larger left planum temporale. Women had larger ventromedial prefrontal cortex (vmPFC), right lateral orbitofrontal (rlOFC), cerebellum, and bilateral basal ganglia and nearby white matter. vmPFC but not rlOFC volume covaried with self-reported emotion regulation strategies (reappraisal, suppression), expressivity of positive emotions (but not of negative), strength of emotional impulses, and cognitive but not somatic anxiety. vmPFC volume statistically mediated sex differences in emotion suppression. The results confirm prior reports of sex differences in orbitofrontal cortex structure, and are the first to show that normal variation in vmPFC volume is systematically related to emotion regulation and affective individual differences.