Circulation. Arrhythmia and electrophysiology
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Circ Arrhythm Electrophysiol · Dec 2014
Multicenter Study Observational StudyProtein biomarkers identify patients unlikely to benefit from primary prevention implantable cardioverter defibrillators: findings from the Prospective Observational Study of Implantable Cardioverter Defibrillators (PROSE-ICD).
Primary prevention implantable cardioverter defibrillators (ICDs) reduce all-cause mortality, but the benefits are heterogeneous. Current risk stratification based on left ventricular ejection fraction has limited discrimination power. We hypothesize that biomarkers for inflammation, neurohumoral activation, and cardiac injury can predict appropriate shocks and all-cause mortality in patients with primary prevention ICDs. ⋯ clinicaltrials.gov; Unique Identifier: NCT00733590.
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Circ Arrhythm Electrophysiol · Dec 2014
Multicenter StudyREPLACE DARE (Death After Replacement Evaluation) score: determinants of all-cause mortality after implantable device replacement or upgrade from the REPLACE registry.
Identifying factors predictive of mortality may be important to decrease risk associated with cardiac implantable electrical device (CIED) replacement procedures. This study aimed to determine whether clinical factors and complications independently associate with death and to develop a mortality risk prediction tool after CIED replacement. ⋯ http://www.clinicaltrials.gov. Unique identifier: NCT00395447.
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Circ Arrhythm Electrophysiol · Dec 2014
Multicenter StudyElectrical storm in patients with brugada syndrome is associated with early repolarization.
Electrical storms (ESs) in patients with Brugada syndrome (BrS) are rare though potentially lethal. ⋯ A high prevalence of ER was found in a subgroup of patients with BrS associated with ES. ES appeared to be suppressed by isoproterenol or quinidine, whereas bepridil and quinidine were effective in the long-term prevention of VF in the highest-risk patients.