Circulation. Cardiovascular imaging
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Circ Cardiovasc Imaging · Sep 2013
Myocardial steatosis and left ventricular contractile dysfunction in patients with severe aortic stenosis.
Aortic stenosis (AS) leads to left ventricular (LV) hypertrophy and dysfunction. We hypothesized that cardiac steatosis is involved in the pathophysiology and also assessed whether it is reversible after aortic valve replacement. ⋯ Pronounced myocardial steatosis is present in severe AS, regardless of symptoms, and is independently associated with the degree of LV strain impairment. Myocardial triglyceride content measured by magnetic resonance spectroscopy correlates with histological quantification. Steatosis and strain impairment are reversible after aortic valve replacement. Our findings suggest a novel pathophysiological mechanism in AS, myocardial steatosis, which may be amenable to treatment, thus potentially delaying onset of LV dysfunction.
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Circ Cardiovasc Imaging · Jul 2013
Randomized Controlled Trial Multicenter StudyPercutaneous mitral valve repair in the initial EVEREST cohort: evidence of reverse left ventricular remodeling.
Percutaneous repair of mitral regurgitation (MR) permits examination of the effect of MR reduction without surgery and cardiopulmonary bypass on left ventricular (LV) dimensions and function. The goal of this analysis was to determine the extent of reverse remodeling at 12 months after successful percutaneous reduction of MR with the MitraClip device. ⋯ URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00209339, NCT00209274.
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Circ Cardiovasc Imaging · Jul 2013
Randomized Controlled TrialEchocardiographic assessment of cardiac valvular regurgitation with lorcaserin from analysis of 3 phase 3 clinical trials.
Lorcaserin is a selective 5-HT2C agonist evaluated for weight management in clinical trials. Echocardiographic monitoring was conducted to test the hypothesis that selective 5-HT2C agonism would avoid valvular heart disease. ⋯ URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00395135, NCT00603291, NCT00603902.