Circulation. Heart failure
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Randomized Controlled Trial Multicenter Study Comparative Study
Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction.
Early studies showed beneficial effects of phosphodiesterase 5 inhibitors on cardiovascular function in heart failure (HF) patients, but the RELAX trial observed no improvement in exercise capacity with sildenafil treatment in subjects with HF and preserved ejection fraction. ⋯ URL: http://www.clinicaltrials.gov. Unique identifier: NCT00094302.
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Multicenter Study Comparative Study
Blood pressure and adverse events during continuous flow left ventricular assist device support.
Adverse events (AEs), such as intracranial hemorrhage, thromboembolic event, and progressive aortic insufficiency, create substantial morbidity and mortality during continuous flow left ventricular assist device support yet their relation to blood pressure control is underexplored. ⋯ In a population at risk, higher DOPBP during continuous flow left ventricular assist device support was significantly associated with a composite of AEs.
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Randomized Controlled Trial Multicenter Study
Regular wine consumption in chronic heart failure: impact on outcomes, quality of life, and circulating biomarkers.
Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. ⋯ URL: http://www.clinicaltrials.gov. Unique identifier: NCT0033633.
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Controlled Clinical Trial
Enhanced pulmonary vasodilator reserve and abnormal right ventricular: pulmonary artery coupling in heart failure with preserved ejection fraction.
Pulmonary hypertension and right ventricular (RV) dysfunction are common in patients with advanced heart failure with preserved ejection fraction (HFpEF), yet their underlying mechanisms remain poorly understood. We sought to examine RV-pulmonary artery (PA) functional reserve responses and RV-PA coupling at rest and during β-adrenergic stimulation in subjects with earlier stage HFpEF. ⋯ URL: http://www.clinicaltrials.gov. Unique identifier: NCT01418248.
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Multicenter Study Comparative Study Observational Study
Effect of estimated plasma volume reduction on renal function for acute heart failure differs between patients with preserved and reduced ejection fraction.
The prognostic relevance of plasma volume reduction (PVR) in acute heart failure patients remains unclear because of the confounding hemodynamic effect of left ventricular ejection fraction impairment on kidney function. ⋯ URL: http://www.umin.ac.jp/ctr/index-j.html. Unique identifier: UMIN000001549.