Injury
-
Review
Pharmacological agents for soft tissue and bone infected with MRSA: which agent and for how long?
Methicillin-resistant Staphylococcus aureus (MRSA) infections cause an important number of soft tissue and bone infections, although exact rates vary across different countries and institutions. The length of antibiotic treatment required depends upon the severity of infection and pre-existing co-morbidities. Monitoring response to treatment is important to ensure cure of infection whilst preventing excessive antibiotic use. ⋯ There are also several agents only available in the intravenous (IV) form, for example glycopeptides, daptomycin and tigecycline. These are normally reserved for the treatment of severe infections. Whilst tissue penetration is variable within this group, it is the adverse events linked with each antibiotic that are most effective in determining the preferred agent.
-
Bone infection in adults is a potentially devastating complication following trauma or surgery. The clinician should diagnose osteomyelitis based on certain clinical manifestations and on laboratory and imaging findings. For pathogen identification, the treating surgeon should take appropriate tissue samples. ⋯ Treatment of chronic osteomyelitis is more complicated. For its eradication the treatment course is often prolonged and frustrating. Based on the current literature an algorithm of treatment for both acute and chronic bone infections is recommended.
-
To evaluate the validity of the 12-item Short Form Health Survey (SF-12), Sickness Impact Profile (SIP) and the Short Musculoskeletal Functional Assessment Questionnaire (SMFA) for use in an orthopaedic trauma population. ⋯ For large population-based surveillance research into orthopaedic injury the SF-12 provides a valid and versatile tool.
-
Complex tibial plateau fractures can be difficult to characterise on plain radiographs and two-dimensional computed tomography (2D CT). The present study evaluated whether three-dimensional computed tomography (3D CT) reconstructions can improve the reliability of complex tibial plateau fracture characterisation and classification. ⋯ The added value of 3D CT after 2D CT is limited and does not significantly improve reliability of characterisation and classification of tibial plateau fractures.
-
Little is known about patients' views or preferences about the route of administration of antimicrobials. In this study semi-structured interviews were carried out to assess patients' perceptions of an infection that required IV antimicrobial therapy in hospital, their preference for intravenous, IV followed by oral and discharge on oral therapy or home IV therapy. Interviews were transcribed and the content analysed. ⋯ Many patients expressed a preference for oral therapy over IV therapy although this was dependent on it being of equal efficacy. Contrary views were related to personal difficulty with tablets. Patients varied in their acceptance of home IV therapy and expressed concern about adequate support but the majority expressed a preference for being discharged on oral therapy once they were well enough.