Injury
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Comparative Study
Comparison of lateral and posterior surgical approach in management of extra-articular distal humeral shaft fractures.
The objective of this study was to compare treatment results and complication rates between lateral and posterior approaches in surgical treatment of extra-articular distal humeral shaft fractures. ⋯ Both lateral and posterior surgical approaches acquired satisfied treatment results in the management of extra-articular distal humeral shaft fractures, and there was a lower complication rate using the lateral approach.
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Although there is much current debate about the use of critical care to enhance peri-operative care of patients with hip fracture there are limited supporting data. We investigated the epidemiology, critical care interventions and outcomes of patients with hip fracture admitted to a large UK critical care unit. ⋯ The major determinants of outcome in this population were reason for admission, and timing of admission to critical care. One year survival was better than that for unselected patients aged >80 years admitted to critical care. Admission to critical care and use of enhanced peri-operative care for selected hip fracture patients is entirely appropriate and beneficial.
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In a previous study, condylar compression bolts and intramedullary nailing with the use of a traditional transpatellar tendon approach were employed for the management of non-impacted complex fractures of the tibia plateau. However, there were intra-operative difficulties, related to the surgical approach that could jeopardise fracture reduction and contribute to sub-optimal outcomes. The purpose of this study is to introduce the retropatellar approach for the management of complex tibial plateau fractures with intramedullary nailing and condylar compression bolts that avoid the pitfalls created by the traditional transpatellar approach.
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Diabetes is one of the most prevalent human metabolic diseases. Wound healing in diabetes is frequently impaired and treatment remains challenging. Sphingolipid metabolites play important roles in the regulation of glucose metabolism. SPK1 is the key enzyme in the sphingolipid metabolic pathway. S1P/SPK plays a pivotal role in the signalling pathways of diverse cellular processes including proliferation, differentiation, migration, apoptosis in diverse cell types. ⋯ SPK1 gene therapy may represent a novel approach to cutaneous wound healing.