Injury
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Cairns Hospital is the northernmost tertiary referral hospital in Far North Queensland (FNQ) and manages trauma from a large catchment area. A large burden of stab injuries occurs in at-risk patient groups, such as Indigenous and mental health patients, in this region. This research aims to present an overview of the demographics, injury patterns, management and outcomes for stabbings injuries in FNQ. ⋯ Stab injuries annually in FNQ are comparable to other centres in Australia. Overall injury severity was low, with excellent survival rates and outcomes for patients who reached hospital. Operative intervention rates for abdominal stab wounds were low in FNQ compared to available data and imaging again appears protective against negative laparotomy rate.
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Meta-analyses constitute fundamental tools of the Evidence-Based Medicine (EBM) aiming at synthesizing outcome data from individual trials in order to produce pooled effect estimates for various outcomes of interest. Combining summary data from several studies increases the sample size, improves the statistical power of the findings as well as the precision of the obtained effect estimates. ⋯ In addition, over the course of the evolution of the current meta-analytic methodology, some concerns have been expressed on the ultimate usefulness of such a complex and time consuming procedure on establishing timely, valid evidence on various specified topics in the field of Orthopaedics and Trauma Surgery. This article provides an overview of the appropriate methodology, benefits and potential drawbacks of the meta-analytic procedure.
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Delayed diagnosis of abdominal injuries and hemorrhagic shock leads to secondary complications and high late mortality in severely traumatized patients. The liver fatty acid-binding protein (L-FABP) is expressed in intestine, liver and kidney; the neutrophil gelatinase-associated lipocalin (NGAL) in colon and kidney. We hypothesized that l-FABP is an early biomarker for abdominal injury and hemorrhagic shock and that l-FABP and NGAL are specific markers for detection of liver and/or kidney injuries. ⋯ L-FABP and NGAL are novel biomarkers for detection of abdominal trauma and hemorrhagic shock. l-FABP may be a useful and promising parameter in diagnosis of liver and kidney injuries, NGAL failed to achieve the same.
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The adoption of evidence-based orthopaedics has shifted the focus from expert base opinions and anecdotal evidence to a focus on integrating the best available clinical research. This shift has led to an increased focus on randomized controlled trials (RCTs) within the field. Although RCTs are considered the highest level of evidence, methodologic errors can introduce bias and limit the validity of the results. Early trials were hampered by lack of blinding, inadequate sample sizes and other design flaws. The objective of this review was to examine the current literature to determine if the design and execution of RCTs has improved. ⋯ Although marked improvements have been made in the design and implementation of trials, there is still considerable room for improvement. Adequately blinded and powered studies evaluating clinically important outcomes and differences should be key considerations in trial design moving forward.