Chemico-biological interactions
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New findings regarding acetylcholinesterase (AChE) in the neuromuscular junction (NMJ), obtained in the last decade, are briefly reviewed. AChE is highly concentrated in the NMJs of vertebrates. Its location remains stable after denervation in mature rat muscles but not in early postnatal muscles. ⋯ It contains domains for binding AChE to basal lamina with ionic and covalent interactions. Muscle activity is required for normal AChE expression in muscles and its accumulation in the NMJs. In addition, the pattern of muscle activation also regulates AChE activity in the NMJs, demonstrating that the pattern of synaptic transmission is able to modulate one of the key synaptic components.
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Chem. Biol. Interact. · Jul 1977
ReviewSome aspects of the mechanisms by which industrial solvents produce neurotoxic effects.
A Short Review is given of the biochemical neurotoxic mechanisms of common industrial solvents of various structures. The acute effects of organic solvents may be caused by their direct action on the nerve cell membrane and energy metabolism, whereas chronic neurotoxic effects may be explained by the formation of chemically and biologically reactive intermediates. The stability of the toxic metabolites appears to correlate with the development of neuropathy although this is structuredependent. The role of reactive intermediates is also emphasized by the potentiating effect of the induction of the cytochrome P-450 complex.