Chest
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Despite the lack of evidence for the effectiveness of physical restraints, their use in patients is widespread. The best ethical justification for restraining patients is that it prevents them from harming themselves. ⋯ These conditions are that the physician obtained informed consent for their application, that their application be medically appropriate, and that restraints be the least liberty-restricting way of achieving the intended benefit. It is a further question whether their application is ever medically appropriate, given the dearth of evidence for their effectiveness.
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Meta Analysis
The accuracy of clinical staging of stage I-IIIa non-small cell lung cancer: An analysis based on individual participant data.
Clinical staging of non-small cell lung cancer (NSCLC) helps determine the prognosis and treatment of patients; few data exist on the accuracy of clinical staging and the impact on treatment and survival of patients. We assessed whether participant or trial characteristics were associated with clinical staging accuracy as well as impact on survival. ⋯ This study demonstrates suboptimal agreement between clinical and pathologic staging. Discrepancies between clinical and pathologic T and N staging could have led to different treatment decisions in 10% and 38% of cases, respectively. There is therefore a need for further research into improving staging accuracy for patients with stage I-IIIa NSCLC.
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Observational Study
Aspirin Use and Respiratory Morbidity in COPD: a Propensity Score Matched Analysis in SPIROMICS.
Aspirin use in COPD has been associated with reduced all-cause mortality in meta-regression analysis with few equivocal studies. However, the effect of aspirin on COPD morbidity is unknown. ⋯ Daily aspirin use is associated with reduced rate of COPD exacerbations, less dyspnea, and better quality of life. Randomized clinical trials of aspirin use in COPD are warranted to account for unmeasured and residual confounding.
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Percutaneous dilatational tracheotomy (PDT) has become increasingly popular and has gained widespread acceptance. The modern PDT procedure has also evolved to whereby it can be safely performed by surgeons and nonsurgeons in the ICU. Moreover, bedside PDT has proven clinical outcomes and can save hospital resources. ⋯ Today, many pulmonologists and intensivists who can use bedside PDT do not perform this procedure; it is conceivable this practice may expand, especially among pulmonologists and intensivists. Although numerous indications exist for tracheostomy, the focus of this article is limited to bedside PDT for prolonged mechanical ventilation, which is the most common indication for this procedure. We describe the logistics and operations needed for programs to incorporate PDT into routine ICU care.
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Tracheobronchial injury is a rare but a potentially high-impact event with significant morbidity and mortality. Common etiologies include blunt or penetrating trauma and iatrogenic injury that might occur during surgery, endotracheal intubation, or bronchoscopy. ⋯ Although there are still some definitive indications for surgery, selected patients who meet traditional surgical criteria as well as those patients who were deemed to be poor surgical candidates can now be managed successfully using minimally invasive techniques. This paradigm shift from surgical to nonsurgical management is promising and should be considered prior to making final management decisions.