Chest
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Comparative Study
A functional and morphologic analysis of pressure-controlled inverse ratio ventilation in oleic acid-induced lung injury.
To compare volume-controlled ventilation (VCV PEEP) with pressure-controlled inverse ratio ventilation (PCIRV) at equal levels of end-expiratory pressure. ⋯ PCIRV was no better than VCV with similar PEEP levels in alveolar recruitment and aeration of the lung tissues or in oxygenating the blood. Cardiac output was lower with PCIRV than with VCV, causing lower oxygen delivery to peripheral tissues. PCIRV does allow for a reduction in minute ventilation and for lowering peak airway pressure.
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The rising healthcare costs and the ethical and economic implications of cardiopulmonary resuscitation (CPR) have generated interest in defining criteria to predict the appropriateness of CPR in specific patients. Age has been proposed as one such a criterion. ⋯ Age alone is not a valid criterion to decide whether a patient is a suitable candidate for CPR, and the principal diagnosis and main comorbidity at the time of admission do not appear to predict long-term survival either. Whether in-hospital CPR in noncritical care areas is cost-effective is an issue that society at large must eventually decide.
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Comparative Study Retracted Publication
Platelet function in critically ill patients.
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the editor In 2018, CHEST published a notice1 that all articles authored by Joachim Boldt be read with caution due to expressions of concern about falsified data. In 2020, CHEST received additional evidence of research misconduct and breaches of scientific integrity that were discovered following an investigation by the author's former institution, the University of Giessen2. ⋯ CHEST 153(3), p. 767. 2. Mukherjee, J. Statement on the scientific credibility of articles published by Joachim Boldt, formerly professor at Justus Liebig University (JLU), Giessen, Germany. https://ars.els-cdn.com/content/image/1-s2.0-S000709122030163X-mmc3.pdf.
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Clinical Trial Controlled Clinical Trial
Spontaneous pneumothorax. Long-term results with tetracycline pleurodesis.
The aim of this prospective study was to determine the rate of recurrence for spontaneous pneumothorax (SP) after tetracycline pleurodesis (TCP), using that of observation, tube thoracostomy alone, and thoracotomy as references. From 1985 to the end of 1991, 78 patients were treated with tetracycline pleurodesis and 135 patients served as control subjects. Pleurodesis was induced by instillation of tetracycline and ascorbic acid through the pleural drain. ⋯ Five deaths were due to respiratory causes and six were due to extrapulmonary causes. Tetracycline pleurodesis has been shown to be a good alternative for the prevention of recurrence of SP. Its recurrence rate is lower than that of tube drainage but higher than that of surgical treatment.