The journal of trauma and acute care surgery
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J Trauma Acute Care Surg · Oct 2012
Comparative StudyClara cell protein 16: A biomarker for detecting secondary respiratory complications in patients with multiple injuries.
Clara cell protein 16 (CC16) has recently gained acceptance as a blood biomarker for detecting direct and indirect lung injury. Although the early elevation of CC16 serum levels has been shown to correlate with pulmonary damage in patients with multiple injuries, the subsequent time course of CC16 serum levels has not been investigated in these patients. ⋯ Diagnostic study, level II.
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J Trauma Acute Care Surg · Oct 2012
Comparative StudyFour serum microRNAs identified as diagnostic biomarkers of sepsis.
Serum microRNAs (miRNAs) can be used as biomarkers for many kinds of diseases, and some are even better than current indicators. The aim of this study was to investigate a diagnostic role for serum miRNAs in sepsis patients. ⋯ II, diagnostic study.
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J Trauma Acute Care Surg · Oct 2012
Comparative StudyThe application of human engineering interventions reduces ventilator-associated pneumonia in trauma patients.
Ventilator-associated pneumonia (VAP) increases mortality and length of stay and escalates the cost of care. Our institution embarked on a project to eradicate VAP. ⋯ Therapeutic study, level IV.
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Military service members are often exposed to at least one explosive event, and many blast-exposed veterans present with symptoms of traumatic brain injury. However, there is little information on the intensity and duration of blast necessary to cause brain injury. ⋯ The first primary blast brain injury risk assessments for mild and moderate/severe injuries in a gyrencephalic animal model were determined. The blast level needed to cause a mild/moderate brain injury may be similar to or less than that needed for pulmonary injury. The risk functions can be used in future research for blast brain injury by providing realistic injury risks to guide the design of protection or evaluate injury.
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J Trauma Acute Care Surg · Oct 2012
Comparative StudyPercutaneous cardiopulmonary support for catastrophic pulmonary fat embolism in pigs.
The purpose of this study was to evaluate the effect of percutaneous cardiopulmonary support (PCPS) for fatal fat embolism. ⋯ PCPS can increase the survival rate of piglets with fatal fat embolism by providing effective cardiopulmonary support. This study suggests that PCPS might be an effective treatment for a patient with severe fat embolism if conventional treatments have not worked.