The journal of trauma and acute care surgery
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J Trauma Acute Care Surg · Mar 2012
Comparative StudyPlatonin mitigates lung injury in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats.
Traumatic hemorrhagic shock and subsequent resuscitation may promote bacteria translocation and cause endotoxemia, a two-hit process that will induce severe lung injury. The pathogenesis involves oxidative stress, neutrophil infiltration, and inflammatory response. Platonin, a potent antioxidant, possesses potent anti-inflammation capacity. We sought to elucidate whether platonin could mitigate acute lung injury in a two-hit model of traumatic hemorrhage/resuscitation and subsequent endotoxemia. ⋯ Platonin mitigates lung injury in a two-hit model of traumatic hemorrhage/resuscitation and endotoxemia in rats.
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J Trauma Acute Care Surg · Mar 2012
Multicenter Study Comparative StudyThe forgotten trauma patient: outcomes for injured patients evaluated by emergency medical services but not transported to the hospital.
Injured patients who are not transported by an ambulance to the hospital are often not included in trauma registries. The outcomes of these patients have until now been unknown. Understanding what happens to nontransports is necessary to better understand triage validity, patient outcomes, and costs associated with injury. We hypothesized that a subset of patients who were not transported from the scene would later present for evaluation and that these patients would have a nonzero mortality rate. ⋯ III, therapeutic study.
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J Trauma Acute Care Surg · Mar 2012
Comparative StudyPredictors of acute posttraumatic stress disorder symptoms following civilian trauma: highest incidence and severity of symptoms after assault.
Posttraumatic stress disorder (PTSD) is associated with significant morbidity following injury. The incidence and risk factors for PTSD are not well described in the civilian trauma population. We proposed to screen all trauma patients in the outpatient trauma clinic for acute PTSD symptoms and identify risk factors for PTSD. ⋯ II.
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J Trauma Acute Care Surg · Mar 2012
Multicenter Study Comparative StudyPrehospital injury deaths--strengthening the case for prevention: nationwide cohort study.
To determine the frequency and characteristics of prehospital deaths compared with hospital deaths in different subpopulations with severe injuries. ⋯ III.
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J Trauma Acute Care Surg · Mar 2012
Comparative StudyVentilator-associated pneumonia: bacteremia and death after traumatic injury.
The implications of bacteremia in critically ill patients are uncertain. Some reports suggest bacteremia is linked to higher mortality whereas others do not. These differences may, in part, be because of differences in patient cohorts. To address the potential independent relationship between bacteremia and outcome, we focused on critically ill trauma patients with ventilator-associated pneumonia (VAP), of whom a significant proportion had concomitant bacteremia. We tested the hypothesis that bacteremia was associated with death in trauma patients who developed VAP. ⋯ VAP with bacteremia is associated with an increased mortality in comparison with VAP alone after severe traumatic injury.