The journal of trauma and acute care surgery
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J Trauma Acute Care Surg · Jun 2014
Recurrent kidney injury in critically ill surgical patients is common and associated with worse outcomes.
Supplemental digital content is available in the text. ⋯ Prognostic and epidemiologic study, level III.
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J Trauma Acute Care Surg · Jun 2014
Improvement of ventilation-induced lung injury in a rodent model by inhibition of inhibitory κB kinase.
Inhibition of nuclear factor κB (NF-κB) activation is a well-know strategy to ameliorate ventilation-induced lung injury (VILI). Inhibitory κB kinase (IKK) plays a key role in the regulation of NF-κB activation. In this study, we determined whether inhibition of IKK by an IKK inhibitor exerts lung protection in a rat model of VILI. ⋯ IKK may be a therapeutic target for VILI. An IKK inhibitor, IKK 16, can dampen VILI in rats. The beneficial effect of the IKK 16 may be mediated through the inhibition of NF-κB pathway and up-regulation of nuclear factor E2-related factor 2-regulated heme oxygenase 1 through the activation of the phosphatidylinositol 3 kinase/Akt.
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J Trauma Acute Care Surg · Jun 2014
Randomized Controlled Trial Multicenter StudyCritical illness-related corticosteroid insufficiency after multiple traumas: a multicenter, prospective cohort study.
Given that the observed prevalence and time course of critical illness-related corticosteroid insufficiency (CIRCI) remain inconsistent in trauma patients, the present study was designed to investigate the prevalence, time course, and effect of CIRCI on the outcome of critically ill patients with multiple injuries. ⋯ Prognostic study, level II.
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J Trauma Acute Care Surg · Jun 2014
Multicenter StudyEvaluation of the performance of French physician-staffed emergency medical service in the triage of major trauma patients.
Proper prehospital triage of trauma patients is a cornerstone for the process of care of trauma patients. In France, emergency physicians perform this process according to a national triage algorithm called Vittel Triage Criteria (VTC), introduced in 2002 to help the triage decision-making process. The aim of this two-center study was to evaluate the performance of the triage process based on the VTC to identify major trauma patients in the Paris area. ⋯ In the Paris area, the French physician-based prehospital triage system for patients with suspicion of major trauma showed a high rate of overtriage and a low rate of undertriage. Criteria of global assessment of speed and mechanism alone were poor predictors of major trauma.
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J Trauma Acute Care Surg · Jun 2014
Comparative StudyAutomated prediction of early blood transfusion and mortality in trauma patients.
Prediction of blood transfusion needs and mortality for trauma patients in near real time is an unrealized goal. We hypothesized that analysis of pulse oximeter signals could predict blood transfusion and mortality as accurately as conventional vital signs (VSs). ⋯ Therapeutic/prognostic study, level II.