The journal of trauma and acute care surgery
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J Trauma Acute Care Surg · Sep 2017
Hydrogen gas inhalation inhibits progression to the "irreversible" stage of shock after severe hemorrhage in rats.
Mortality of hemorrhagic shock primarily depends on whether or not the patients can endure the loss of circulating volume until radical treatment is applied. We investigated whether hydrogen (H2) gas inhalation would influence the tolerance to hemorrhagic shock and improve survival. ⋯ H2 gas inhalation delays the progression to irreversible shock. Clinically, H2 gas inhalation is expected to stabilize the subject until curative treatment can be performed, thereby increasing the probability of survival after hemorrhagic shock.
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J Trauma Acute Care Surg · Sep 2017
Review Meta AnalysisIncidence of adult respiratory distress syndrome in trauma patients: A systematic review and meta-analysis over a period of three decades.
In trauma patients, acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality. Changes in diagnostics, management, and treatment may have influenced the incidence of ARDS. Therefore, the purpose of this article is to evaluate whether there is a difference in the incidence of posttraumatic ARDS (1) over time, (2) attributable to geographic distribution, and 3) related to admitting surgical subspecialities. ⋯ Systematic review, level III.
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J Trauma Acute Care Surg · Sep 2017
ReviewAssociation between adipokines and critical illness outcomes.
Adipose tissue is an endocrine organ that plays a critical role in immunity and metabolism by virtue of a large number of hormones and cytokines, collectively termed adipokines. Dysregulation of adipokines has been linked to the pathogenesis of multiple diseases, but some questions have arisen concerning the value of adipokines in critical illness setting. The objective of this review was to evaluate the associations between blood adipokines and critical illness outcomes. ⋯ Systematic review, level III.
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J Trauma Acute Care Surg · Sep 2017
Thrombin generation profiles as predictors of symptomatic venous thromboembolism after trauma: A prospective cohort study.
Reliable biomarkers predictive of venous thromboembolism (VTE) after acute trauma are uncertain. The objective of the study was to identify risk factors for symptomatic VTE after trauma, including individual plasma coagulome characteristics as reflected by thrombin generation. ⋯ Prognostic, level III.
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J Trauma Acute Care Surg · Sep 2017
Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma hemorrhage.
Platelets play a critical role in hemostasis with aberrant function implicated in trauma-induced coagulopathy. However, the impact of massive transfusion protocols on platelet function during trauma hemorrhage is unknown. The aim of this study was to characterize the effects of platelet transfusion on platelet aggregation and fibrinolytic markers during hemostatic resuscitation. ⋯ Therapeutic, level III.